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| Shenmue II | Shenmue | Dreamcast, Xbox | Japan | 2001 |
| Shenmue III | Shenmue | PlayStation 4, Windows | Japan | 2019 |
| Sherlock Holmes jagt Arsène Lupin | Sherlock Holmes | Windows | Ukraine | 2007 |
| Sherlock Holmes jagt Jack the Ripper | Sherlock Holmes | Windows, Xbox 360 | Ukraine | 2009 |
| Sherlock Holmes: Crimes & Punishments | Sherlock Holmes | Windows, PlayStation 3, PlayStation 4, Xbox 360, Xbox One, Nintendo Switch | Ukraine | 2014 |
| Sherlock Holmes: Das Geheimnis des silbernen Ohrrings | Sherlock Holmes | Windows, Wii | Ukraine | 2004 |
| Sherlock Holmes: Die Spur der Erwachten | Sherlock Holmes | Windows | Ukraine | 2006 |
| Sherlock Holmes: The Devil’s Daughter | Sherlock Holmes | Windows, PlayStation 4, Xbox One, Nintendo Switch | Ukraine | 2016 |
| ShinobiRB | Shinobi | PlayStation 2 | Japan | 2002 |
| Shinobi | Shinobi | Arcade | Japan | 1987 |
| Shinobi II: The Silent Fury | Shinobi | Japan | 1992 | |
| Shinobi III: Return of the Ninja Master | Shinobi | Japan | 1993 | |
| Shinobi X | Shinobi | Japan | 1995 | |
| Siege of Avalon | Windows | Vereinigte Staaten | 2000 | |
| Silent Hill | Silent Hill | PlayStation | Japan | 1999 |
| Silent Hill 2RM | Silent Hill | Windows, PlayStation 5 | Polen | 2024 |
| Silent Hill 2 | Silent Hill | PlayStation 2, Xbox, Windows | Japan | 2001 |
| Silent Hill 3 | Silent Hill | PlayStation 2, Windows | Japan | 2003 |
| Silent Hill 4: The Room | Silent Hill | PlayStation 2, Xbox, Windows | Japan | 2004 |
| Silent Hill: Downpour | Silent Hill | PlayStation 3, Xbox 360 | Tschechien | 2012 |
| Silent Hill: Homecoming | Silent Hill | PlayStation 3, Xbox 360, Windows | Vereinigte Staaten | 2008 |
| Silent Hill: Origins | Silent Hill | PlayStation Portable, PlayStation 2 | England, Vereinigte Staaten | 2007 |
| Silver | Windows, Dreamcast, macOS, Linux | England | 1999 | |
| Simon the Sorcerer | Simon the Sorcerer | MS-DOS, Acorn Archimedes | England | 1993 |
| Simon the Sorcerer 3D | Simon the Sorcerer | Windows | England | 2003 |
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