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| Simon the Sorcerer II | Simon the Sorcerer | MS-DOS, Windows, macOS, Amiga | England | 1995 |
| Siren: Blood Curse | Siren | PlayStation 3 | Japan | 2008 |
| Sly 2: Band of Thieves | Sly Cooper | PlayStation 2 | Vereinigte Staaten | 2004 |
| Sly 3: Honor Among Thieves | Sly Cooper | PlayStation 2 | Vereinigte Staaten | 2005 |
| Sly Cooper: Jagd durch die Zeit | Sly Cooper | PlayStation 3, PlayStation Vita | Vereinigte Staaten | 2013 |
| Sly Raccoon | Sly Cooper | PlayStation 2 | Vereinigte Staaten | 2002 |
| Snake’s Revenge | Metal GearSO | Nintendo | Japan | 1990 |
| Soldier of Fortune | Soldier of Fortune | Windows, Linux, Dreamcast, PlayStation 2 | Vereinigte Staaten | 2000 |
| Soldier of Fortune II: Double Helix | Soldier of Fortune | Windows, macOS, Xbox | Vereinigte Staaten | 2002 |
| Soldier of Fortune: Payback | Soldier of Fortune | Windows, Xbox 360, PlayStation 3 | Slowakei | 2007 |
| Soma | Windows, macOS, Linux, PlayStation 4, Xbox One | Schweden | 2015 | |
| Song of Horror | Windows, PlayStation 4, Xbox One, Xbox Series | Spanien | 2019 | |
| Sons of the Forest | The Forest | Windows | Kanada | 2023 |
| SOS: The Final Escape | Disaster Report | PlayStation 2 | Japan | 2002 |
| Soul Blazer | GaiaIO | Super Nintendo | Japan | 1992 |
| Soul Calibur | Soul Calibur | Japan | 1998 | |
| Soul Calibur II | Soul Calibur | Japan | 2002 | |
| Soul Calibur III | Soul Calibur | Japan | 2005 | |
| Soul Calibur IV | Soul Calibur | PlayStation 3, Xbox 360 | Japan | 2008 |
| Soul Calibur V | Soul Calibur | PlayStation 3, Xbox 360 | Japan | 2012 |
| Soul Reaver 2: The Legacy of Kain Series | Legacy of Kain | PlayStation 2, Windows | Vereinigte Staaten | 2001 |
| Soulcalibur VIRB | Soul Calibur | Windows, PlayStation 4, Xbox One | Japan | 2018 |
| South Park: Der Stab der Wahrheit | South Park | Windows, PlayStation 3, Xbox 360, PlayStation 4, Xbox One, Nintendo Switch | Vereinigte Staaten | 2014 |
| South Park: Die rektakuläre Zerreißprobe | South Park | Windows, PlayStation 4, Xbox One, Nintendo Switch | Vereinigte Staaten | 2017 |
| Spec Ops: Ranger Assault | Spec Ops | Windows | Vereinigte Staaten | 1998 |
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