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| Story of Seasons: Friends of Mineral TownRM | Story of Seasons | Nintendo Switch, Windows, PlayStation 4, Xbox One | Japan | 2019 |
| Stranger of Paradise: Final Fantasy Origin | Final FantasySO | Windows, PlayStation 4, PlayStation 5, Xbox One, Xbox Series | Japan | 2022 |
| Stray | Windows, PlayStation 4, PlayStation 5 | Frankreich | 2022 | |
| Street Fighter | Street Fighter | Japan | 1987 | |
| Street Fighter II | Street Fighter | Japan | 1991 | |
| Street Fighter II Turbo | Street Fighter | Japan | 1992 | |
| Street Fighter 6 | Street Fighter | Windows, PlayStation 4, PlayStation 5, Xbox Series | Japan | 2023 |
| Streets of Rage | Streets of Rage | Japan | 1991 | |
| Streets of Rage II | Streets of Rage | Japan | 1993 | |
| Streets of Rage 3 | Streets of Rage | Sega Genesis | Japan | 1994 |
| Streets of Rage 4 | Streets of Rage | Windows, PlayStation 4, Xbox One, Nintendo Switch, macOS, Linux, Android, iOS | Frankreich, Vereinigte Staaten | 2020 |
| Stubbs the Zombie in Rebel Without a Pulse | Xbox, Windows, macOS, PlayStation 4, PlayStation 5, Xbox One, Xbox Series, Nintendo Switch | Vereinigte Staaten | 2005 | |
| Subnautica | Subnautica | Windows, macOS, PlayStation 4, Xbox One, PlayStation 5, Xbox Series, Nintendo Switch | Vereinigte Staaten | 2014 |
| Subnautica: Below Zero | Subnautica | Windows, macOS, PlayStation 4, Xbox One, PlayStation 5, Xbox Series, Nintendo Switch | Vereinigte Staaten | 2019 |
| Suikoden | Suikoden | PlayStation, Sega Saturn, Windows | Japan | 1995 |
| Suikoden I & II HD Remaster: Gate Rune and Dunan Unification WarsRS | Suikoden | Windows, PlayStation 4, Xbox One, Nintendo Switch | Japan | 2023 |
| Suikoden II | Suikoden | PlayStation, Windows | Japan | 1998 |
| Suikoden III | Suikoden | PlayStation 2 | Japan | 2002 |
| Suikoden IV | Suikoden | PlayStation 2 | Japan | 2004 |
| Suikoden V | Suikoden | PlayStation 2 | Japan | 2006 |
| Suikoden Tactics | SuikodenSO | PlayStation 2 | Japan | 2005 |
| Suikoden Tierkreis | SuikodenSO | Nintendo DS | Japan | 2008 |
| Summoner | Summoner | PlayStation 2, Windows, macOS | Vereinigte Staaten | 2000 |
| Summoner 2 | Summoner | PlayStation 2, GameCube | Vereinigte Staaten | 2002 |
| Sunless Sea | Fallen London | Windows, PlayStation 4, Nintendo Switch, Xbox One | England | 2014 |
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